Monoamines and neuropeptides interact to inhibit aversive behaviour inCaenorhabditis elegans
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منابع مشابه
Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans.
Pain modulation is complex, but noradrenergic signalling promotes anti-nociception, with α(2)-adrenergic agonists used clinically. To better understand the noradrenergic/peptidergic modulation of nociception, we examined the octopaminergic inhibition of aversive behaviour initiated by the Caenorhabditis elegans nociceptive ASH sensory neurons. Octopamine (OA), the invertebrate counterpart of no...
متن کاملMonoamines and neuropeptides interact to inhibit aversive behavior in Caenorhabditis elegans
As you can see the referees find the analysis interesting, but also indicate that that some more analysis is needed to fully support the conclusions and for the manuscript to have the full impact of an EMBO Journal paper. I will not repeat all the issues here as they are clearly indicated below. Given the referees' comments I would like to invite you to submit a suitably revised manuscript shou...
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The metaphase to anaphase transition is a critical stage of the eukaryotic cell cycle, and, thus, it is highly regulated. Errors during this transition can lead to chromosome segregation defects and death of the organism. In genetic screens for temperature-sensitive maternal effect embryonic lethal (Mel) mutants, we have identified 32 mutants in the nematode Caenorhabditis elegans in which fert...
متن کاملThe monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmission.
Monoamines and neuropeptides interact to modulate behavioral plasticity in both vertebrates and invertebrates. In Caenorhabditis elegans behavioral state or "mood" is dependent on food availability and is translated by both monoaminergic and peptidergic signaling in the fine-tuning of most behaviors. In the present study, we have examined the interaction of monoamines and peptides on C. elegans...
متن کاملNeuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans.
Monoamines and neuropeptides interact to modulate most behaviors. To better understand these interactions, we have defined the roles of tyramine (TA), octopamine, and neuropeptides in the inhibition of aversive behavior in Caenorhabditis elegans. TA abolishes the serotonergic sensitization of aversive behavior mediated by the two nociceptive ASH sensory neurons and requires the expression of th...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2011
ISSN: 0261-4189
DOI: 10.1038/emboj.2011.422